Objective review of the genesis of important uranium deposits in the United States suggests that many of the basic assumptions pertaining to source, mobilization and fixation are inadequate or even potentially erroneous. Analysis of empirical evidence, supported by modern uranium geochemistry research, has resulted in a number of genetic concepts that drastically broaden the geological and geographical scope of uranium exploration. Under especially favourable mobilizing conditions, the primary source of uranium deposits may be deceptively low-grade as well as being obscured, making transport and fixation the basic exploration problems. Mechanisms other than fixation by organic reductants are considered in proposing exploration models. Future reconnaissance should be guided by a multi-conceptual approach assisted by appropriate geological, geophysical and geochemical methods, as opposed to the present heavy dependence on drilling, prospect evaluation and a generally singular depositional model.