Royal Society Publishing

Organization of cell–regulatory systems through modular–protein–interaction domains

Tony Pawson

Abstract

Cells are organized through the interactions of proteins with one another, and with phospholipids, nucleic acids and small molecules, suggesting a molecular recognition code for cell assembly. These interactions are mediated by a set of conserved protein interaction domains, which regulate the dynamic behaviour of the cell, and are used to build protein complexes and networks with emergent properties. Cell regulatory proteins have a modular architecture, which may have facilitated the evolution of new signalling pathways, and is exploited by pathogenic micro–organisms and chimeric oncoproteins to re–specify cellular function.

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